Ipamorelin

Ipamorelin is a synthetic pentapeptide that functions as a potent and selective growth hormone secretagogue (GHS). It is an agonist of the ghrelin/growth hormone secretagogue receptor (GHS-R1a). In research settings, Ipamorelin is highly valued for its specificity, mimicking the GH-stimulating actions of endogenous ghrelin without the associated side effects observed with older generation secretagogues. Preclinical…

Description

Research & Mechanisms

1. Selective GH Release Stimulation The primary distinction of Ipamorelin in research is its selectivity. Unlike other GHRPs (such as GHRP-2 or GHRP-6), studies have demonstrated that Ipamorelin stimulates pituitary growth hormone release without inducing significant elevations in cortisol (the stress hormone) or prolactin. This makes it an ideal tool for isolating GH-specific physiological responses in animal models.

2. Gastric Motility and Metabolism As a ghrelin receptor agonist, Ipamorelin is investigated for its influence on gastrointestinal motility and energy homeostasis. Researchers study its potential effects on gastric emptying rates and bowel function in experimental models of gastrointestinal dysmotility.

3. Bone Health and Nitrogen Retention Beyond acute GH release, long-term administration in animal studies is researched for downstream effects on Insulin-like Growth Factor 1 (IGF-1) levels. Areas of investigation include its potential role in increasing bone mineral density (BMD), promoting nitrogen retention, and influencing body composition toward lean tissue accretion.