Description

Research & Mechanisms

1. Cardiolipin Interaction and Cristae Stabilization The primary mechanism of SS-31 involves its selective binding to cardiolipin, a phospholipid unique to the inner mitochondrial membrane. Research suggests that SS-31 stabilizes cardiolipin, preventing the structural disruption of the mitochondrial cristae. This interaction helps optimize the curvature of the membrane required for the efficient function of the electron transport chain (ETC).

2. Reduction of ROS and Oxidative Stress By interacting with the cytochrome c/cardiolipin complex, SS-31 has been observed to inhibit the peroxidase activity of cytochrome c. In preclinical models, this action significantly reduces the production of mitochondrial Reactive Oxygen Species (ROS) without inhibiting the oxidative phosphorylation necessary for ATP production.

3. Ischemic Protection SS-31 is widely researched for its cytoprotective effects during ischemic events (lack of blood flow). Animal studies indicate that administration of the peptide can preserve organ function and reduce tissue damage during reperfusion, particularly in cardiac and renal models.