KPV-10

KPV is a naturally occurring tripeptide consisting of the amino acids Lysine, Proline, and Valine. It represents the C-terminal fragment of alpha-melanocyte-stimulating hormone (α-MSH). Unlike the full α-MSH hormone, KPV does not stimulate melanogenesis (pigmentation), making it a specific tool for researching potent anti-inflammatory and antimicrobial pathways without pigmentary side effects. In research settings, KPV…

Description

Research & Mechanisms

1. Anti-Inflammatory Action (NF-κB Inhibition) The primary mechanism of KPV involves the inhibition of the NF-κB pathway, a key regulator of inflammation. Research models suggest that KPV can penetrate cells and directly reduce the expression of pro-inflammatory cytokines (such as TNF-α and IL-6). It is frequently studied in models of ulcerative colitis and psoriasis for its ability to calm localized inflammation.

2. Antimicrobial and Antifungal Activity KPV exhibits significant antimicrobial properties. It is a subject of interest in research regarding Staphylococcus aureus and specifically Candida albicans. Studies indicate that KPV can inhibit yeast budding and hyphal formation, preventing fungal adhesion and colonization in mucosal tissues.

3. Wound Healing and Scar Reduction Experimental data suggests that KPV accelerates wound healing by reducing the inflammatory phase that often leads to excessive scarring. By modulating the immune response at the site of injury, it is researched for its potential to minimize fibrosis and improve cosmetic outcomes in tissue repair models.