Description

Research & Mechanisms

1. AMPK Activation and Metabolic Flexibility The primary mechanism of MOTS-c involves the activation of the AMPK (Adenosine Monophosphate-activated Protein Kinase) pathway. Research indicates that MOTS-c acts similarly to an “exercise mimetic” by targeting the folate-methionine cycle. Studies in murine models have shown that this activation promotes fatty acid oxidation and inhibits lipid accumulation, even under high-fat diet conditions.

2. Insulin Sensitivity and Glucose Regulation MOTS-c is a key subject in diabetes and obesity research. Preclinical data suggests that administration of the peptide can enhance whole-body insulin sensitivity. It is studied for its ability to improve glucose uptake in skeletal muscle and suppress hepatic glucose production, countering the effects of diet-induced obesity and insulin resistance.

3. Physical Performance and Endurance Researchers investigate MOTS-c for its impact on physical capacity. Studies have demonstrated that MOTS-c treatment can significantly improve running performance and endurance in young and old mice, suggesting it plays a critical role in ameliorating age-related decline in physical function and muscle metabolism