SLU-PP-322

SLU-PP-322 is a synthetic small molecule that acts as a potent agonist of the Estrogen-Related Receptors (ERRs), with high selectivity for the ERRα and ERRγ isoforms. Unlike traditional ligands that target hormonal receptors, this compound regulates metabolic pathways directly associated with cellular energy expenditure and mitochondrial biogenesis, often referred to in literature as an “exercise…

Description

Research & Mechanisms

1. Mitochondrial Biogenesis and Function The primary mechanism of action involves the activation of the ERRα-PGC1α signaling pathway. Research indicates that this interaction stimulates the creation of new mitochondria (mitochondrial biogenesis) and enhances their oxidative capacity. Laboratory models have shown increased endurance and fatigue resistance in skeletal muscle tissues treated with this agonist.

2. Fatty Acid Oxidation SLU-PP-322 is studied for its potential to shift cellular metabolism towards utilizing fatty acids as a primary fuel source. Preclinical data suggests that it promotes the expression of genes involved in lipid oxidation, leading to a reduction in fat mass accumulation even in the absence of caloric restriction.

3. Type II Muscle Fiber Transformation Studies in rodent models have observed a transformation in skeletal muscle composition, increasing the proportion of oxidative (Type IIa) muscle fibers. This physiological shift is typically only seen after extensive endurance training, further supporting its classification as an exercise mimetic in research applications.